Potent Thrombolytic (breaking up of blood clots) Activity

The human body produces several types of enzymes for making thrombus (blood clots that obstruct a blood vessel or a cavity of the heart), but only one main enzyme for breaking it down and dissolving it - plasmin. According to Dr. Martin Milner, what makes nattokinase a particularly potent treatment, is that it enhances the body's natural ability to fight blood clots in several different ways. Because it so closely resembles plasmin, it dissolves fibrin directly. In addition, it also enhances the body's production of both plasmin and other clot-dissolving agents, including urokinase (endogenous). "In some ways, Dr. Milner says, nattokinese is actually superior to clot-dissolving drugs. These drugs often fail-they are only effective when taken intravenously and often fail simply because a stroke or heart attack victim's arteries have hardened beyond the point where they can be treated by any other clot-dissolving agent. Nattokinase, however, can help prevent that hardening with an oral dose of as little as 100 mg a day."

How Natto-Z Works

Healthy circulation occurs when your blood flows smoothly. Nattokinase doesn't inhibit blood clot formation; it actually works to support the circulatory system by assisting the fibrinolytic blood clearing system, which breaks down cross-linked fibrin protein deposits in the blood. Healthy circulation can do wonders to support total health. When circulation is not balanced, tissues don't get enough nutrients and blood does not clear enough wastes away. Systemic enzymes such as nattokinase support healthy circulation so that tissues can get the nutrients delivered and wastes removed - the way healthy blood circulation should work in the body. Fibrin is a protein that naturally forms in the blood after trauma or injury. Fibrin may also form in the absence of any trauma or injury. When unhealthy fibrin formation occurs, there are major implications for cardiovascular health.

These BAD consequences can include:

• Formation of unhealthy blood clots
• Increased blood viscosity (thicker)
• Impaired circulation
• Effects on blood pressure
• Blood cells are more likely to stick to vessel walls, especially veins, in a process that further encourages the development of unhealthy clots

Discovery

Dr. Hiroyuki Sumi, MD, a researcher of the Japan Ministry of Education and majoring in physiological chemistry at the blood laboratory of the University of Chicago, had long researched thrombolytic enzymes searching for a natural agent that could successfully dissolve thrombus associated with cardiac and cerebral infarction (blood clots associated with heart attacks and stroke) Sumi discovered nattokinase in 1980 after testing over 173 natural foods as potential "blood clot dissolving" agents. Dr. Sumi found that the sticky part of natto, commonly called "threads", exhibited a strong fibrinolytic ("blood clot dissolving") activity. Natto was dropped onto artificial thrombus (fibrin) in a Petri dish and allowed to stand at 37 C (approximate body temperature). The thrombus around the natto dissolved gradually and had completely dissolved within 18 hours. He named the corresponding fibrinolytic enzyme "nattokinase". Dr. Sumi commented that nattokinase showed "a potency matched by no other enzyme."

Research

Japanese natto has been the subject of 17 studies, including two small human trials. Researchers from JCR Pharmaceuticals, Oklahoma State University, and Miyazaki Medical College tested nattokinase on 12 healthy Japanese volunteers (6 men and 6 women, between the ages of 21 and 55). They gave the volunteers 200 grams of bacillus natto (the food) before breakfast, then tracked fibrinolytic activity through a series of blood plasma tests. The tests indicated that the bacillus natto generated a heightened ability to dissolve blood clots. On average, the volunteers' ELT (a measure of how long it takes to dissolve a blood clot) dropped by 48% within two hours of treatment, and volunteers retained an enhanced ability to dissolve blood clots for 2 to 8 hours. An additional study showed nattokinase as a herbal treatment for high blood pressure with an 11% decrease in blood pressure after just two weeks.

 References:

1. Natto-Traditional Japanese Fermented Soy Beans with Recently Discovered Health Benefits and Novel Industrial Applications, Enzyme Wave, Volume 3, June 2002, Amano Enzyme, Inc., page 2-4.
2. Sumi H. Healthy Microbe “Bacillus natto”. Japan Bio Science Laboratory Co. Ltd.
3. Maruyama M. Sumi H. Effect of Natto Diet on Blood Pressure. JTTAS, 1995
4. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H, A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia 1987, Oct 15;43(10): 1110-1.

 

 

 

 

 

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